Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4653031 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Wang Junyun J Ding Nan N Li Yongjun Y Cheng Hua H Wang Dong D Yang Qiong Q Deng Youhui Y Yang Yaran Y Li Yanming Y Ruan Xiuyan X Xie Fang F Zhao Hua H Fang Xiangdong X
Oncotarget 20150801 24
The insulin-like growth factor binding protein 5 (IGFBP5), which is often dysregulated in human cancers, plays a crucial role in carcinogenesis and cancer development. However, the function and underlying mechanism of IGFBP5 in tumor growth and metastasis has been elusive, particularly in malignant human melanoma. Here, we reported that IGFBP5 acts as an important tumor suppressor in melanoma tumorigenicity and metastasis by a series of experiments including transwell assay, xenograft model, in ...[more]