Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi M
PROVIDER: S-EPMC4653156 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Takeuchi Miki M Fuse Yuji Y Watanabe Mana M Andrea Christina-Sylvia CS Takeuchi Miho M Nakajima Hitomi H Ohashi Ken K Kaneko Hiroshi H Kobayashi-Osaki Maki M Yamamoto Masayuki M Kobayashi Makoto M
Proceedings of the National Academy of Sciences of the United States of America 20151028 45
The hemangioblast is a progenitor cell with the capacity to give rise to both hematopoietic and endothelial progenitors. Currently, the regulatory mechanisms underlying hemangioblast formation are being elucidated, whereas those controllers for the selection of hematopoietic or endothelial fates still remain a mystery. To answer these questions, we screened for zebrafish mutants that have defects in the hemangioblast expression of Gata1, which is never expressed in endothelial progenitors. One o ...[more]