Ontology highlight
ABSTRACT:
SUBMITTER: Schureck MA
PROVIDER: S-EPMC4653167 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Schureck Marc A MA Dunkle Jack A JA Maehigashi Tatsuya T Miles Stacey J SJ Dunham Christine M CM
Proceedings of the National Academy of Sciences of the United States of America 20151027 45
Bacteria contain multiple type II toxins that selectively degrade mRNAs bound to the ribosome to regulate translation and growth and facilitate survival during the stringent response. Ribosome-dependent toxins recognize a variety of three-nucleotide codons within the aminoacyl (A) site, but how these endonucleases achieve substrate specificity remains poorly understood. Here, we identify the critical features for how the host inhibition of growth B (HigB) toxin recognizes each of the three A-sit ...[more]