Ontology highlight
ABSTRACT:
SUBMITTER: Antonucci L
PROVIDER: S-EPMC4653219 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Antonucci Laura L Fagman Johan B JB Kim Ju Youn JY Todoric Jelena J Gukovsky Ilya I Mackey Mason M Ellisman Mark H MH Karin Michael M
Proceedings of the National Academy of Sciences of the United States of America 20151028 45
Pancreatic acinar cells possess very high protein synthetic rates as they need to produce and secrete large amounts of digestive enzymes. Acinar cell damage and dysfunction cause malnutrition and pancreatitis, and inflammation of the exocrine pancreas that promotes development of pancreatic ductal adenocarcinoma (PDAC), a deadly pancreatic neoplasm. The cellular and molecular mechanisms that maintain acinar cell function and whose dysregulation can lead to tissue damage and chronic pancreatitis ...[more]