Ontology highlight
ABSTRACT:
SUBMITTER: Nie Y
PROVIDER: S-EPMC4653243 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Nie Yingchao Y Li Qi Q Amcheslavsky Alla A Duhart Juan Carlos JC Veraksa Alexey A Stocker Hugo H Raftery Laurel A LA Ip Y Tony YT
Stem cell reviews and reports 20151201 6
The Drosophila adult midgut contains intestinal stem cells that support homeostasis and repair. We show here that the leucine zipper protein Bunched and the adaptor protein Madm are novel regulators of intestinal stem cells. MARCM mutant clonal analysis and cell type specific RNAi revealed that Bunched and Madm were required within intestinal stem cells for proliferation. Transgenic expression of a tagged Bunched showed a cytoplasmic localization in midgut precursors, and the addition of a nucle ...[more]