Ontology highlight
ABSTRACT:
SUBMITTER: Chi H
PROVIDER: S-EPMC4653635 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Chi Haixia H Wang Xiaoqiang X Li Jiqiang J Ren Hao H Huang Fang F
Scientific reports 20151120
The in vitro folding of newly translated human CC chemokine receptor type 5 (CCR5), which belongs to the physiologically important family of G protein-coupled receptors (GPCRs), has been studied in a cell-free system supplemented with the surfactant Brij-35. The freshly synthesized CCR5 can spontaneously fold into its biologically active state but only slowly and inefficiently. However, on addition of the GroEL-GroES molecular chaperone system, the folding of the nascent CCR5 was significantly e ...[more]