Ontology highlight
ABSTRACT:
SUBMITTER: Shen L
PROVIDER: S-EPMC4653673 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Shen Li L Macnaughtan Megan A MA Frohlich Kyla M KM Cong Yanguang Y Goodwin Octavia Y OY Chou Chau-Wen CW LeCour Louis L Krup Kristen K Luo Miao M Worthylake David K DK
The Journal of biological chemistry 20151005 47
Secretion of effector proteins into the eukaryotic host cell is required for Chlamydia trachomatis virulence. In the infection process, Scc1 and Scc4, two chaperones of the type III secretion (T3S) system, facilitate secretion of the important effector and plug protein, CopN, but little is known about the details of this event. Here we use biochemistry, mass spectrometry, nuclear magnetic resonance spectroscopy, and genetic analyses to characterize this trimolecular event. We find that Scc4 comp ...[more]