Ontology highlight
ABSTRACT:
SUBMITTER: Altman MK
PROVIDER: S-EPMC4654121 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Altman Molly K MK Alshamrani Ali A AA Jia Wei W Nguyen Ha T HT Fambrough Jada M JM Tran Sterling K SK Patel Mihir B MB Hoseinzadeh Pooya P Beedle Aaron M AM Murph Mandi M MM
Cancer letters 20150828 1
The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activate mTOR. Since RGS10 suppression augments ovarian cancer cell viability, we sought to elucidate the molecular mechanism. Following RGS10 suppression in serum-free conditions, phosphorylation of mTOR, ...[more]