Ontology highlight
ABSTRACT:
SUBMITTER: Thomas KA
PROVIDER: S-EPMC4654252 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Thomas K A KA Valenzuela N M NM Gjertson D D Mulder A A Fishbein M C MC Parry G C GC Panicker S S Reed E F EF
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20150422 8
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells. While F(ab')2 portions of DSA cause cellular activation and proliferation, Fc regions activate the classical complement cascade, resulting in complement deposition and leukocyte recruitment, both hallmark features of AMR. We characterized the ability of an anti-C1s monoclonal ...[more]