Ontology highlight
ABSTRACT:
SUBMITTER: Do LH
PROVIDER: S-EPMC4654439 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Do Long H LH Mobley William C WC Singhal Nishant N
F1000Research 20150717
Recently, in studies examining fibroblasts obtained from the tissues of one set of monozygotic twins (i.e. fetuses derived from the same egg) discordant for trisomy 21 (Down syndrome; DS), Letourneau et al., ( )reported the presence of a defined pattern of dysregulation within specific genomic domains they referred to as Gene Expression Dysregulated Domains (GEDDs). GEDDs were described as alternating segments of increased or decreased gene expression affecting all chromosomes. Strikingly, GEDDs ...[more]