Ontology highlight
ABSTRACT:
SUBMITTER: Scull MA
PROVIDER: S-EPMC4654572 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
PLoS pathogens 20151120 11
The hepatitis C virus (HCV) p7 protein is required for infectious virus production via its role in assembly and ion channel activity. Although NMR structures of p7 have been reported, the location of secondary structural elements and orientation of the p7 transmembrane domains differ among models. Furthermore, the p7 structure-function relationship remains unclear. Here, extensive mutagenesis, coupled with infectious virus production phenotyping and molecular modeling, demonstrates that the N-te ...[more]