Ontology highlight
ABSTRACT:
SUBMITTER: Gagnon D
PROVIDER: S-EPMC4654618 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Gagnon David D Sénéchal Hélène H D'Abramo Claudia M CM Alvarez Jennifer J McBride Alison A AA Archambault Jacques J
Virology 20130311 2
The bovine papillomavirus type 1 (BPV1) E2 protein binds as a dimer to the viral genome to promote its transcription, replication and maintenance in keratinocytes. Although BPV1 E2 dimerizes primarily through its DNA-binding domain, it was shown previously that its transactivation domain (TAD) can also dimerize in vitro through formation of a disulfide bond between cysteine 57 (C57) of adjacent monomers and of an ion pair between arginine 172 (R172) and aspartic acid 175 (D175). The function of ...[more]