Ontology highlight
ABSTRACT:
SUBMITTER: Waddell A
PROVIDER: S-EPMC4654638 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Waddell Amanda A Vallance Jefferson E JE Moore Preston D PD Hummel Amy T AT Wu David D Shanmukhappa Shiva K SK Fei Lin L Washington M Kay MK Minar Phillip P Coburn Lori A LA Nakae Susumu S Wilson Keith T KT Denson Lee A LA Hogan Simon P SP Rosen Michael J MJ
Inflammatory bowel diseases 20151201 12
<h4>Background</h4>IL-33, a member of the IL-1 cytokine family that signals through ST2, is upregulated in ulcerative colitis (UC); however, the role of IL-33 in colitis remains unclear. IL-33 augments type 2 immune responses, which have been implicated in UC pathogenesis. We sought to determine the role of IL-33 signaling in oxazolone (OXA) colitis, a type 2 cytokine-mediated murine model of UC.<h4>Methods</h4>Colon mucosal IL-33 expression was compared between pediatric and adult UC and non-IB ...[more]