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Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD Without ID: A Multi-site Study.


ABSTRACT: Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised algorithm demonstrated increased sensitivity, but lower specificity in the overall sample. Estimates were highest for females, individuals with a verbal IQ below 85 or above 115, and ages 16 and older. Best practice diagnostic procedures should include the Module 4 in conjunction with other assessment tools. Balancing needs for sensitivity and specificity depending on the purpose of assessment (e.g., clinical vs. research) and demographic characteristics mentioned above will enhance its utility.

SUBMITTER: Pugliese CE 

PROVIDER: S-EPMC4654671 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD Without ID: A Multi-site Study.

Pugliese Cara E CE   Kenworthy Lauren L   Bal Vanessa Hus VH   Wallace Gregory L GL   Yerys Benjamin E BE   Maddox Brenna B BB   White Susan W SW   Popal Haroon H   Armour Anna Chelsea AC   Miller Judith J   Herrington John D JD   Schultz Robert T RT   Martin Alex A   Anthony Laura Gutermuth LG  

Journal of autism and developmental disorders 20151201 12


Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised algorithm demonstrated increased sensitivity, but lower specificity in the overall sample. Estimates were highest for females, individuals with a verbal  ...[more]

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