Ontology highlight
ABSTRACT:
SUBMITTER: Huebsch N
PROVIDER: S-EPMC4654683 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Huebsch Nathaniel N Lippens Evi E Lee Kangwon K Mehta Manav M Koshy Sandeep T ST Darnell Max C MC Desai Rajiv M RM Madl Christopher M CM Xu Maria M Zhao Xuanhe X Chaudhuri Ovijit O Verbeke Catia C Kim Woo Seob WS Alim Karen K Mammoto Akiko A Ingber Donald E DE Duda Georg N GN Mooney David J DJ
Nature materials 20150914 12
The effectiveness of stem cell therapies has been hampered by cell death and limited control over fate. These problems can be partially circumvented by using macroporous biomaterials that improve the survival of transplanted stem cells and provide molecular cues to direct cell phenotype. Stem cell behaviour can also be controlled in vitro by manipulating the elasticity of both porous and non-porous materials, yet translation to therapeutic processes in vivo remains elusive. Here, by developing i ...[more]