Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain.
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ABSTRACT:
SUBMITTER: Salbaum JM
PROVIDER: S-EPMC4655353 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain.
Salbaum J Michael JM Kruger Claudia C MacGowan Jacalyn J Herion Nils J NJ Burk David D Kappen Claudia C
Scientific reports 20151123
Failure to close the neural tube results in birth defects, with severity ranging from spina bifida to lethal anencephaly. Few genetic risk factors for neural tube defects are known in humans, highlighting the critical role of environmental risk factors, such as maternal diabetes. Yet, it is not well understood how altered maternal metabolism interferes with embryonic development, and with neurulation in particular. We present evidence from two independent mouse models of diabetic pregnancy that ...[more]
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