Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC4655568 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Wang Rui R Stone Rebecca L RL Kaelber Jason T JT Rochat Ryan H RH Nick Alpa M AM Vijayan K Vinod KV Afshar-Kharghan Vahid V Schmid Michael F MF Dong Jing-Fei JF Sood Anil K AK Chiu Wah W
Proceedings of the National Academy of Sciences of the United States of America 20151102 46
Thrombocytosis and platelet hyperreactivity are known to be associated with malignancy; however, there have been no ultrastructure studies of platelets from patients with ovarian cancer. Here, we used electron cryotomography (cryo-ET) to examine frozen-hydrated platelets from patients with invasive ovarian cancer (n = 12) and control subjects either with benign adnexal mass (n = 5) or free from disease (n = 6). Qualitative inspections of the tomograms indicate significant morphological differenc ...[more]