Ontology highlight
ABSTRACT:
SUBMITTER: Ziv E
PROVIDER: S-EPMC4656791 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Ziv Elad E Dean Eric E Hu Donglei D Martino Alessandro A Serie Daniel D Curtin Karen K Campa Daniele D Aftab Blake B Bracci Paige P Buda Gabriele G Zhao Yi Y Caswell-Jin Jennifer J Diasio Robert R Dumontet Charles C Dudziński Marek M Fejerman Laura L Greenberg Alexandra A Huntsman Scott S Jamroziak Krzysztof K Jurczyszyn Artur A Kumar Shaji S Atanackovic Djordje D Glenn Martha M Cannon-Albright Lisa A LA Jones Brandt B Lee Adam A Marques Herlander H Martin Thomas T Martinez-Lopez Joaquin J Rajkumar Vincent V Sainz Juan J Vangsted Annette Juul AJ Wątek Marzena M Wolf Jeffrey J Slager Susan S Camp Nicola J NJ Canzian Federico F Vachon Celine C
Nature communications 20150722
Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the associ ...[more]