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Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.


ABSTRACT: Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients.

SUBMITTER: Ziv E 

PROVIDER: S-EPMC4656791 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.

Ziv Elad E   Dean Eric E   Hu Donglei D   Martino Alessandro A   Serie Daniel D   Curtin Karen K   Campa Daniele D   Aftab Blake B   Bracci Paige P   Buda Gabriele G   Zhao Yi Y   Caswell-Jin Jennifer J   Diasio Robert R   Dumontet Charles C   Dudziński Marek M   Fejerman Laura L   Greenberg Alexandra A   Huntsman Scott S   Jamroziak Krzysztof K   Jurczyszyn Artur A   Kumar Shaji S   Atanackovic Djordje D   Glenn Martha M   Cannon-Albright Lisa A LA   Jones Brandt B   Lee Adam A   Marques Herlander H   Martin Thomas T   Martinez-Lopez Joaquin J   Rajkumar Vincent V   Sainz Juan J   Vangsted Annette Juul AJ   Wątek Marzena M   Wolf Jeffrey J   Slager Susan S   Camp Nicola J NJ   Canzian Federico F   Vachon Celine C  

Nature communications 20150722


Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the associ  ...[more]

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