Ontology highlight
ABSTRACT:
SUBMITTER: Terakawa T
PROVIDER: S-EPMC4656996 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Terakawa Tsuyoshi T Takada Shoji S
Scientific reports 20151124
p53 is a representative transcription factor that activates multiple target genes. To realize stimulus-dependent specificities, p53 has to recognize targets with structural variety, of which molecular mechanisms are largely unknown. Here, we conducted a series of long-time scale (totally more than 100-ms) coarse-grained molecular dynamics simulations, uncovering structure and dynamics of full-length p53 tetramer that recognizes its response element (RE). We obtained structures of a full-length p ...[more]