Ontology highlight
ABSTRACT:
SUBMITTER: Tinganelli W
PROVIDER: S-EPMC4657060 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Tinganelli Walter W Durante Marco M Hirayama Ryoichi R Krämer Michael M Maier Andreas A Kraft-Weyrather Wilma W Furusawa Yoshiya Y Friedrich Thomas T Scifoni Emanuele E
Scientific reports 20151124
Solid tumours often present regions with severe oxygen deprivation (hypoxia), which are resistant to both chemotherapy and radiotherapy. Increased radiosensitivity as a function of the oxygen concentration is well described for X-rays. It has also been demonstrated that radioresistance in anoxia is reduced using high-LET radiation rather than conventional X-rays. However, the dependence of the oxygen enhancement ratio (OER) on radiation quality in the regions of intermediate oxygen concentration ...[more]