Ontology highlight
ABSTRACT:
SUBMITTER: Feiler MS
PROVIDER: S-EPMC4657165 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Feiler Marisa S MS Strobel Benjamin B Freischmidt Axel A Helferich Anika M AM Kappel Julia J Brewer Bryson M BM Li Deyu D Thal Dietmar R DR Walther Paul P Ludolph Albert C AC Danzer Karin M KM Weishaupt Jochen H JH
The Journal of cell biology 20151101 4
Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-like domain-containing protein and component of pathological intracellular aggregates found in most amyotrophic lateral sclerosis (ALS) patients. TDP-43 oligomers have been postulated to be released and subsequently nucleate TDP-43 oligomerization in recipient cells, which might be the molecular correlate of the systematic symptom spreading observed during ALS progression. We developed a novel protein complemen ...[more]