Ontology highlight
ABSTRACT:
SUBMITTER: Brodovitch A
PROVIDER: S-EPMC4657482 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Brodovitch Alexandre A Shenderov Eugene E Cerundolo Vincenzo V Bongrand Pierre P Pierres Anne A van der Merwe Philip Anton PA
European journal of immunology 20150421 6
T lymphocytes need to detect rare cognate foreign peptides among numerous foreign and self-peptides. This discrimination seems to be based on the kinetics of TCRs binding to their peptide-MHC (pMHC) ligands, but there is little direct information on the minimum time required for processing elementary signaling events and deciding to initiate activation. Here, we used interference reflection microscopy to study the early interaction between transfected human Jurkat T cells expressing the 1G4 TCR ...[more]