Ontology highlight
ABSTRACT:
SUBMITTER: Lagana A
PROVIDER: S-EPMC4657999 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Laganà Alessandro A Veneziano Dario D Spata Tyler T Tang Richard R Zhu Hua H Mohler Peter J PJ Kilic Ahmet A
PloS one 20151124 11
MicroRNAs (miRNAs or miRs) are small regulatory RNAs crucial for modulation of signaling pathways in multiple organs. While the link between miRNAs and heart disease has grown more readily apparent over the past three years, these data are primarily limited to small animal models or cell-based systems. Here, we performed a high-throughput RNA sequencing (RNAseq) analysis of left ventricle and other tissue from a pre-clinical ovine model. We identified 172 novel miRNA precursors encoding a total ...[more]