Ontology highlight
ABSTRACT:
SUBMITTER: Grassi E
PROVIDER: S-EPMC4658012 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Grassi Elena E Zapparoli Ettore E Molineris Ivan I Provero Paolo P
PloS one 20151124 11
Transcription factors regulate gene expression by binding regulatory DNA. Understanding the rules governing such binding is an essential step in describing the network of regulatory interactions, and its pathological alterations. We show that describing regulatory regions in terms of their profile of total binding affinities for transcription factors leads to increased predictive power compared to methods based on the identification of discrete binding sites. This applies both to the prediction ...[more]