Ontology highlight
ABSTRACT:
SUBMITTER: Kanatsou S
PROVIDER: S-EPMC4658081 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kanatsou Sofia S Fearey Brenna C BC Kuil Laura E LE Lucassen Paul J PJ Harris Anjanette P AP Seckl Jonathan R JR Krugers Harm H Joels Marian M
PloS one 20151123 11
Exposure to chronic stress is a risk factor for cognitive decline and psychopathology in genetically predisposed individuals. Preliminary evidence in humans suggests that mineralocorticoid receptors (MRs) may confer resilience to these stress-related changes. We specifically tested this idea using a well-controlled mouse model for chronic stress in combination with transgenic MR overexpression in the forebrain. Exposure to unpredictable stressors for 21 days in adulthood reduced learning and mem ...[more]