Unknown

Dataset Information

0

Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.


ABSTRACT: Interleukin (IL)-15 has multiple roles in innate and adaptive immunity, especially regarding CD8+ T cells and natural killer cells. However, the role of IL-15 in regulating differentiation of T helper cell subsets and mononuclear phagocytes (MPs) in different tissues in vivo is unknown. Here we report that IL-15 indirectly regulates Th17 but not other Th subsets in the intestinal lamina propria (LP), apparently through effects on MPs. Th17 cells in the LP were more prevalent in IL-15 KO mice than their wild-type counterparts, and less prevalent in IL-15 transgenic mice than their wild-type littermates, even co-caged. MPs from the LP of these mice were sufficient to mimic the in vivo finding in vitro by skewing of cocultured wild type OVA-specific CD4+ T cells. However, production of IL-15 or lack thereof by these MPs was not sufficient to explain the skewing, as addition or blockade of IL-15 in the cultures had no effect. Rather, a skewing of the relative proportion of CD11b+, CD103+ and double positive LP MP subsets in transgenic and KO could explain the differences in Th17 cells. Thus, IL-15 may influence MP subsets in the gut in a novel way that alters the frequency of LP Th17 cells.

SUBMITTER: Yu H 

PROVIDER: S-EPMC4658142 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.

Yu Huifeng H   Sui Yongjun Y   Wang Yichuan Y   Sato Noriko N   Frey Blake B   Xia Zheng Z   Waldmann Thomas A TA   Berzofsky Jay J  

PloS one 20151123 11


Interleukin (IL)-15 has multiple roles in innate and adaptive immunity, especially regarding CD8+ T cells and natural killer cells. However, the role of IL-15 in regulating differentiation of T helper cell subsets and mononuclear phagocytes (MPs) in different tissues in vivo is unknown. Here we report that IL-15 indirectly regulates Th17 but not other Th subsets in the intestinal lamina propria (LP), apparently through effects on MPs. Th17 cells in the LP were more prevalent in IL-15 KO mice tha  ...[more]

Similar Datasets

2023-01-17 | GSE161987 | GEO
2023-01-17 | GSE162062 | GEO
| S-EPMC2556461 | biostudies-literature
| S-EPMC4918233 | biostudies-literature
| S-EPMC2323677 | biostudies-literature
2012-07-11 | E-GEOD-22877 | biostudies-arrayexpress
2012-07-12 | GSE22877 | GEO
| S-EPMC3732523 | biostudies-literature
| S-EPMC6717263 | biostudies-literature
| S-EPMC8126652 | biostudies-literature