Ontology highlight
ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC4658142 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yu Huifeng H Sui Yongjun Y Wang Yichuan Y Sato Noriko N Frey Blake B Xia Zheng Z Waldmann Thomas A TA Berzofsky Jay J
PloS one 20151123 11
Interleukin (IL)-15 has multiple roles in innate and adaptive immunity, especially regarding CD8+ T cells and natural killer cells. However, the role of IL-15 in regulating differentiation of T helper cell subsets and mononuclear phagocytes (MPs) in different tissues in vivo is unknown. Here we report that IL-15 indirectly regulates Th17 but not other Th subsets in the intestinal lamina propria (LP), apparently through effects on MPs. Th17 cells in the LP were more prevalent in IL-15 KO mice tha ...[more]