Ontology highlight
ABSTRACT:
SUBMITTER: Da Silva DM
PROVIDER: S-EPMC4658296 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Da Silva Diane M DM Woodham Andrew W AW Skeate Joseph G JG Rijkee Laurie K LK Taylor Julia R JR Brand Heike E HE Muderspach Laila I LI Roman Lynda D LD Yessaian Annie A AA Pham Huyen Q HQ Matsuo Koji K Lin Yvonne G YG McKee Greg M GM Salazar Andres M AM Kast W Martin WM
Clinical immunology (Orlando, Fla.) 20150908 2
Human papillomavirus (HPV)-mediated suppression of Langerhans cell (LC) function can lead to persistent infection and development of cervical intraepithelial neoplasia (CIN). Women with HPV-induced high-grade CIN2/3 have not mounted an effective immune response against HPV, yet it is unknown if LC-mediated T cell activation from such women is functionally impaired against HPV. We investigated the functional activation of in vitro generated LC and their ability to induce HPV16-specific T cells fr ...[more]