Ontology highlight
ABSTRACT:
SUBMITTER: Diana D
PROVIDER: S-EPMC4658480 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Diana Donatella D De Rosa Lucia L Palmieri Maddalena M Russomanno Anna A Russo Luigi L La Rosa Carmelo C Milardi Danilo D Colombo Giorgio G D'Andrea Luca D LD Fattorusso Roberto R
Scientific reports 20151125
HPLW, a designed VEGF (Vascular Endothelium Growth Factor) receptor-binding peptide, assumes a well folded β-hairpin conformation in water and is able to induce angiogenesis in vivo. In this study, we investigated at atomic resolution the thermal folding/unfolding pathway of HPLW by means of an original multi-technique approach combining DSC, NMR, MD and mutagenesis analyses. In particular, careful NMR investigation of the single proton melting temperatures together with DSC analysis accurately ...[more]