Ontology highlight
ABSTRACT:
SUBMITTER: Williams C
PROVIDER: S-EPMC4658703 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Williams Christopher C Hoppe Hans-Jürgen HJ Rezgui Dellel D Strickland Madeleine M Forbes Briony E BE Grutzner Frank F Frago Susana S Ellis Rosamund Z RZ Wattana-Amorn Pakorn P Prince Stuart N SN Zaccheo Oliver J OJ Nolan Catherine M CM Mungall Andrew J AJ Jones E Yvonne EY Crump Matthew P MP Hassan A Bassim AB
Science (New York, N.Y.) 20121101 6111
Placental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively. M6P/IGF2R of birds and fish do not recognize IGF2. In monotremes, which lack imprinting, IGF2 specifically bound M6P/IGF2R via a hydrophobic CD loop. We show that the DNA coding the CD loop ...[more]