Correlation between GATA4 gene polymorphism and congenital heart disease.

ABSTRACT: OBJECTIVE:The correlation between GATA4 gene polymorphism and congenital heart disease (CHD) was analyzed. METHOD:Clinical data and blood samples were collected from 350 CHD patients who were treated at the Department of Cardiology in Beijing Anzhen Hospital. The control group consisted of 350 healthy subjects receiving physical examination at our hospital during the same period. Polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis for locus rs11392441 of GATA4 gene. RESULTS:Polymorphism of locus rs1139244 of GATA4 gene was detected in CHD patients. The distribution frequencies of GG genotype and G allele were significantly higher than those of the control group. CONCLUSION:Polymorphism of locus rs1139244 of GATA4 gene was correlated with CHD.

SUBMITTER: Yang XY 

PROVIDER: S-EPMC4659101 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature