VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires.
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ABSTRACT:
SUBMITTER: Shugay M
PROVIDER: S-EPMC4659587 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires.
Shugay Mikhail M Bagaev Dmitriy V DV Turchaninova Maria A MA Bolotin Dmitriy A DA Britanova Olga V OV Putintseva Ekaterina V EV Pogorelyy Mikhail V MV Nazarov Vadim I VI Zvyagin Ivan V IV Kirgizova Vitalina I VI Kirgizov Kirill I KI Skorobogatova Elena V EV Chudakov Dmitriy M DM
PLoS computational biology 20151125 11
Despite the growing number of immune repertoire sequencing studies, the field still lacks software for analysis and comprehension of this high-dimensional data. Here we report VDJtools, a complementary software suite that solves a wide range of T cell receptor (TCR) repertoires post-analysis tasks, provides a detailed tabular output and publication-ready graphics, and is built on top of a flexible API. Using TCR datasets for a large cohort of unrelated healthy donors, twins, and multiple scleros ...[more]
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