Ontology highlight
ABSTRACT:
SUBMITTER: Dobb KS
PROVIDER: S-EPMC4659657 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Dobb Katharine S KS Kaye Sarah J SJ Beckmann Nicola N Thain John L JL Stateva Lubomira L Birch Mike M Oliver Jason D JD
PloS one 20151125 11
Antifungal drugs acting via new mechanisms of action are urgently needed to combat the increasing numbers of severe fungal infections caused by pathogens such as Candida albicans. The phosphopantetheinyl transferase of Aspergillus fumigatus, encoded by the essential gene pptB, has previously been identified as a potential antifungal target. This study investigated the function of its orthologue in C. albicans, PPT2/C1_09480W by placing one allele under the control of the regulatable MET3 promote ...[more]