Ontology highlight
ABSTRACT:
SUBMITTER: Kwan JJ
PROVIDER: S-EPMC4660885 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Kwan James J JJ Myers Rachel R Coviello Christian M CM Graham Susan M SM Shah Apurva R AR Stride Eleanor E Carlisle Robert C RC Coussios Constantin C CC
Small (Weinheim an der Bergstrasse, Germany) 20150821 39
Ultrasound-induced bubble activity (cavitation) has been recently shown to actively transport and improve the distribution of therapeutic agents in tumors. However, existing cavitation-promoting agents are micron-sized and cannot sustain cavitation activity over prolonged time periods because they are rapidly destroyed upon ultrasound exposure. A novel ultrasound-responsive single-cavity polymeric nanoparticle (nanocup) capable of trapping and stabilizing gas against dissolution in the bloodstre ...[more]