Synthesis, antimicrobial and cytotoxicity evaluation of new cholesterol congeners.
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ABSTRACT:
SUBMITTER: Aly MR
PROVIDER: S-EPMC4661006 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Synthesis, antimicrobial and cytotoxicity evaluation of new cholesterol congeners.
Aly Mohamed Ramadan El Sayed MR Saad Hosam Ali HA Abdel-Hafez Shams Hashim SH
Beilstein journal of organic chemistry 20151016
3β-Azidocholest-5-ene (3) and (3β)-3-(prop-2-yn-1-yloxy)cholest-5-ene (10) were prepared as substrates to synthesize a variety of three-motif pharmacophoric conjugates through CuAAC. Basically, these conjugates included cholesterol and 1,2,3-triazole moieties, while the third, the pharmacophore, was either a chalcone, a lipophilic residue or a carbohydrate tag. These compounds were successfully prepared in good yields and characterized by NMR, MS and IR spectroscopic techniques. Chalcone conjuga ...[more]
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