Ontology highlight
ABSTRACT:
SUBMITTER: Pezze MA
PROVIDER: S-EPMC4661036 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20150731 11
Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selective dopamine D1 receptor agonist SKF81297 on acquisition and retrieval in the novel object recognition task in male Wistar rats. SKF81297 (0.4 and 0.8 mg/kg s.c.) given 15 min before the sampling phase impaired novel object recognition evaluated 10 min or 24 h later. T ...[more]