Systems Genetic Validation of the SNP-Metabolite Association in Rice Via Metabolite-Pathway-Based Phenome-Wide Association Scans.
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ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC4661230 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Systems Genetic Validation of the SNP-Metabolite Association in Rice Via Metabolite-Pathway-Based Phenome-Wide Association Scans.
Lu Yaping Y Liu Yemao Y Niu Xiaohui X Yang Qingyong Q Hu Xuehai X Zhang Hong-Yu HY Xia Jingbo J
Frontiers in plant science 20151127
In the post-GWAS (Genome-Wide Association Scan) era, the interpretation of GWAS results is crucial to screen for highly relevant phenotype-genotype association pairs. Based on the single genotype-phenotype association test and a pathway enrichment analysis, we propose a Metabolite-pathway-based Phenome-Wide Association Scan (M-PheWAS) to analyze the key metabolite-SNP pairs in rice and determine the regulatory relationship by assessing similarities in the changes of enzymes and downstream produc ...[more]
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