Ontology highlight
ABSTRACT:
SUBMITTER: Prade E
PROVIDER: S-EPMC4661391 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Prade Elke E Bittner Heiko J HJ Sarkar Riddhiman R Lopez Del Amo Juan Miguel JM Althoff-Ospelt Gerhard G Multhaup Gerd G Hildebrand Peter W PW Reif Bernd B
The Journal of biological chemistry 20150928 48
Alzheimer disease is the most severe neurodegenerative disease worldwide. In the past years, a plethora of small molecules interfering with amyloid-β (Aβ) aggregation has been reported. However, their mode of interaction with amyloid fibers is not understood. Non-steroidal anti-inflammatory drugs (NSAIDs) are known γ-secretase modulators; they influence Aβ populations. It has been suggested that NSAIDs are pleiotrophic and can interact with more than one pathomechanism. Here we present a magic a ...[more]