Ontology highlight
ABSTRACT:
SUBMITTER: Huang F
PROVIDER: S-EPMC4661393 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Huang Fu F Ramakrishnan Saravanan S Pokhrel Srijana S Pflueger Christian C Parnell Timothy J TJ Kasten Margaret M MM Currie Simon L SL Bhachech Niraja N Horikoshi Masami M Graves Barbara J BJ Cairns Bradley R BR Bhaskara Srividya S Chandrasekharan Mahesh B MB
The Journal of biological chemistry 20151008 48
Histone H3 lysine 4 (H3K4) methylation is a dynamic modification. In budding yeast, H3K4 methylation is catalyzed by the Set1-COMPASS methyltransferase complex and is removed by Jhd2, a JMJC domain family demethylase. The catalytic JmjC and JmjN domains of Jhd2 have the ability to remove all three degrees (mono-, di-, and tri-) of H3K4 methylation. Jhd2 also contains a plant homeodomain (PHD) finger required for its chromatin association and H3K4 demethylase functions. The Jhd2 PHD finger associ ...[more]