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In vitro follicle growth supports human oocyte meiotic maturation.

ABSTRACT: In vitro follicle growth is a potential approach to preserve fertility for young women who are facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our two-step follicle culture strategy recapitulated the dynamic human follicle growth environment in vitro. Follicles developed from the preantral to antral stage, and, for the first time, produced meiotically competent metaphase II (MII) oocytes after in vitro maturation (IVM).

SUBMITTER: Xiao S 

PROVIDER: S-EPMC4661442 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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In vitro follicle growth supports human oocyte meiotic maturation.

Xiao Shuo S   Zhang Jiyang J   Romero Megan M MM   Smith Kristin N KN   Shea Lonnie D LD   Woodruff Teresa K TK  

Scientific reports 20151127

In vitro follicle growth is a potential approach to preserve fertility for young women who are facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our two-step follicle culture strategy recapitulated the dynamic human follicle growth environment in vitro. Follicles developed from the preantral to antral stage, and, for the first time, produced meiotically competent metaphase II (MII) oocytes after in vitro maturation (IVM). ...[more]

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