Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients.

ABSTRACT:

Background

Acute myeloid leukemia (AML) patients with highly active AKT tend to do poorly. Cell cycle arrest and apoptosis are tightly regulated by AKT via phosphorylation of GSK3α and β isoforms which inactivates these kinases. In the current study we examine the prognostic role of AKT mediated GSK3 phosphorylation in AML.

Methods

We analyzed GSK3α/β phosphorylation by reverse phase protein analysis (RPPA) in a cohort of 511 acute myeloid leukemia (AML) patients. Levels of phosphorylated GSK3 were correlated with patient characteristics including survival and with expression of other proteins important in AML cell survival.

Results

High levels of p-GSK3α/β correlated with adverse overall survival and a lower incidence of complete remission duration in patients with i

SUBMITTER: Ruvolo PP 

PROVIDER: S-EPMC4661707 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature