Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
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ABSTRACT:
SUBMITTER: Day FR
PROVIDER: S-EPMC4661791 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
Day Felix R FR Ruth Katherine S KS Thompson Deborah J DJ Lunetta Kathryn L KL Pervjakova Natalia N Chasman Daniel I DI Stolk Lisette L Finucane Hilary K HK Sulem Patrick P Bulik-Sullivan Brendan B Esko Tõnu T Johnson Andrew D AD Elks Cathy E CE Franceschini Nora N He Chunyan C Altmaier Elisabeth E Brody Jennifer A JA Franke Lude L LL Huffman Jennifer E JE Keller Margaux F MF McArdle Patrick F PF Nutile Teresa T Porcu Eleonora E Robino Antonietta A Rose Lynda M LM Schick Ursula M UM Smith Jennifer A JA Teumer Alexander A Traglia Michela M Vuckovic Dragana D Yao Jie J Zhao Wei W Albrecht Eva E Amin Najaf N Corre Tanguy T Hottenga Jouke-Jan JJ Mangino Massimo M Smith Albert V AV Tanaka Toshiko T Abecasis Goncalo G Andrulis Irene L IL Anton-Culver Hoda H Antoniou Antonis C AC Arndt Volker V Arnold Alice M AM Barbieri Caterina C Beckmann Matthias W MW Beeghly-Fadiel Alicia A Benitez Javier J Bernstein Leslie L Bielinski Suzette J SJ Blomqvist Carl C Boerwinkle Eric E Bogdanova Natalia V NV Bojesen Stig E SE Bolla Manjeet K MK Borresen-Dale Anne-Lise AL Boutin Thibaud S TS Brauch Hiltrud H Brenner Hermann H Brüning Thomas T Burwinkel Barbara B Campbell Archie A Campbell Harry H Chanock Stephen J SJ Chapman J Ross JR Chen Yii-Der Ida YI Chenevix-Trench Georgia G Couch Fergus J FJ Coviello Andrea D AD Cox Angela A Czene Kamila K Darabi Hatef H De Vivo Immaculata I Demerath Ellen W EW Dennis Joe J Devilee Peter P Dörk Thilo T Dos-Santos-Silva Isabel I Dunning Alison M AM Eicher John D JD Fasching Peter A PA Faul Jessica D JD Figueroa Jonine J Flesch-Janys Dieter D Gandin Ilaria I Garcia Melissa E ME García-Closas Montserrat M Giles Graham G GG Girotto Giorgia G GG Goldberg Mark S MS González-Neira Anna A Goodarzi Mark O MO Grove Megan L ML Gudbjartsson Daniel F DF Guénel Pascal P Guo Xiuqing X Haiman Christopher A CA Hall Per P Hamann Ute U Henderson Brian E BE Hocking Lynne J LJ Hofman Albert A Homuth Georg G Hooning Maartje J MJ Hopper John L JL Hu Frank B FB Huang Jinyan J Humphreys Keith K Hunter David J DJ Jakubowska Anna A Jones Samuel E SE Kabisch Maria M Karasik David D Knight Julia A JA Kolcic Ivana I Kooperberg Charles C Kosma Veli-Matti VM Kriebel Jennifer J Kristensen Vessela V Lambrechts Diether D Langenberg Claudia C Li Jingmei J Li Xin X Lindström Sara S Liu Yongmei Y Luan Jian'an J Lubinski Jan J Mägi Reedik R Mannermaa Arto A Manz Judith J Margolin Sara S Marten Jonathan J Martin Nicholas G NG Masciullo Corrado C Meindl Alfons A Michailidou Kyriaki K Mihailov Evelin E Milani Lili L Milne Roger L RL Müller-Nurasyid Martina M Nalls Michael M Neale Ben M BM Nevanlinna Heli H Neven Patrick P Newman Anne B AB Nordestgaard Børge G BG Olson Janet E JE Padmanabhan Sandosh S Peterlongo Paolo P Peters Ulrike U Petersmann Astrid A Peto Julian J Pharoah Paul D P PDP Pirastu Nicola N NN Pirie Ailith A Pistis Giorgio G Polasek Ozren O Porteous David D Psaty Bruce M BM Pylkäs Katri K Radice Paolo P Raffel Leslie J LJ Rivadeneira Fernando F Rudan Igor I Rudolph Anja A Ruggiero Daniela D Sala Cinzia F CF Sanna Serena S Sawyer Elinor J EJ Schlessinger David D Schmidt Marjanka K MK Schmidt Frank F Schmutzler Rita K RK Schoemaker Minouk J MJ Scott Robert A RA Seynaeve Caroline M CM Simard Jacques J Sorice Rossella R Southey Melissa C MC Stöckl Doris D Strauch Konstantin K Swerdlow Anthony A Taylor Kent D KD Thorsteinsdottir Unnur U Toland Amanda E AE Tomlinson Ian I Truong Thérèse T Tryggvadottir Laufey L Turner Stephen T ST Vozzi Diego D Wang Qin Q Wellons Melissa M Willemsen Gonneke G Wilson James F JF Winqvist Robert R Wolffenbuttel Bruce B H R BBHR Wright Alan F AF Yannoukakos Drakoulis D Zemunik Tatijana T Zheng Wei W Zygmunt Marek M Bergmann Sven S Boomsma Dorret I DI Buring Julie E JE Ferrucci Luigi L Montgomery Grant W GW Gudnason Vilmundur V Spector Tim D TD van Duijn Cornelia M CM Alizadeh Behrooz Z BZ Ciullo Marina M Crisponi Laura L Easton Douglas F DF Gasparini Paolo P PP Gieger Christian C Harris Tamara B TB Hayward Caroline C Kardia Sharon L R SLR Kraft Peter P McKnight Barbara B Metspalu Andres A Morrison Alanna C AC Reiner Alex P AP Ridker Paul M PM Rotter Jerome I JI Toniolo Daniela D Uitterlinden André G AG Ulivi Sheila S Völzke Henry H Wareham Nicholas J NJ Weir David R DR Yerges-Armstrong Laura M LM Price Alkes L AL Stefansson Kari K Visser Jenny A JA Ong Ken K KK Chang-Claude Jenny J Murabito Joanne M JM Perry John R B JRB Murray Anna A
Nature genetics 20150928 11
Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in de ...[more]