Ontology highlight
ABSTRACT:
SUBMITTER: Beck TN
PROVIDER: S-EPMC4662460 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Beck Tim N TN Kaczmar John J Handorf Elizabeth E Nikonova Anna A Dubyk Cara C Peri Suraj S Lango Miriam M Ridge John A JA Serebriiskii Ilya G IG Burtness Barbara B Golemis Erica A EA Mehra Ranee R
Oncotarget 20150801 22
Locally advanced squamous cell carcinoma of the head and neck (SCCHN) that is not associated with human papillomavirus (HPV) has a poor prognosis in contrast to HPV-positive disease. To better understand the importance of RB1 activity in HPV-negative SCCHN, we investigated the prognostic value of inhibitory CDK4/6 phosphorylation of RB1 on threonine 356 (T356) in archival HPV-negative tumor specimens from patients who underwent surgical resection and adjuvant radiation. We benchmarked pT356RB1 t ...[more]