Ontology highlight
ABSTRACT:
SUBMITTER: Bousquet G
PROVIDER: S-EPMC4662490 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Bousquet Guilhem G El Bouchtaoui Morad M Leboeuf Christophe C Battistella Maxime M Varna Mariana M Ferreira Irmine I Plassa Louis-François LF Hamdan Diaddin D Bertheau Philippe P Feugeas Jean-Paul JP Damotte Diane D Janin Anne A
Oncotarget 20150801 22
Renal Cell Carcinomas (RCCs) are heterogeneous tumors with late acquisition of TP53 abnormalities during their evolution. They harbor TP53 abnormalities in their metastases. We aimed to study TP53 gene alterations in tissue samples from primary and metastatic RCCs in 36 patients followed up over a median of 4.2 years, and in xenografted issued from primary RCCs. In 36 primary RCCs systematically xenografted in mice, and in biopsies of metastases performed whenever possible during patient follow- ...[more]