Ontology highlight
ABSTRACT:
SUBMITTER: Rege M
PROVIDER: S-EPMC4662874 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cell reports 20151112 8
The histone variant H2A.Z is a hallmark of nucleosomes flanking promoters of protein-coding genes and is often found in nucleosomes that carry lysine 56-acetylated histone H3 (H3-K56Ac), a mark that promotes replication-independent nucleosome turnover. Here, we find that H3-K56Ac promotes RNA polymerase II occupancy at many protein-coding and noncoding loci, yet neither H3-K56Ac nor H2A.Z has a significant impact on steady-state mRNA levels in yeast. Instead, broad effects of H3-K56Ac or H2A.Z o ...[more]