A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes.
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ABSTRACT:
SUBMITTER: Ma P
PROVIDER: S-EPMC4662907 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
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A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes.
Ma Pengpeng P de Waal Eric E Weaver Jamie R JR Bartolomei Marisa S MS Schultz Richard M RM
Cell reports 20151112 8
Maternal genomic imprints are established during oogenesis. Histone deacetylases (HDACs) 1 and 2 are required for oocyte development in mouse, but their role in genomic imprinting is unknown. We find that Hdac1:Hdac2(-/-) double-mutant growing oocytes exhibit global DNA hypomethylation and fail to establish imprinting marks for Igf2r, Peg3, and Srnpn. Global hypomethylation correlates with increased retrotransposon expression and double-strand DNA breaks. Nuclear-associated DNMT3A2 is reduced in ...[more]
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