Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC4663121 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Xu Xiaoping X Steffensen Bjorn B Robichaud Trista K TK Mikhailova Margarita M Lai Veronica V Montgomery Ryan R Chu Lianrui L
Anaerobe 20151009
While FbpA, a family of bacterial fibronectin (FN) binding proteins has been studied in several gram-positive bacteria, the gram-negative Treponema denticola, an anaerobic periodontal pathogen, also has an overlooked fbp gene (tde1579). In this research, we confirm that recombinant Fbp protein (rFbp) of T. denticola binds human FN with a Kdapp of 1.5 × 10(-7) M and blocks the binding of T. denticola to FN in a concentration-dependent manner to a level of 42%. The fbp gene was expressed in T. den ...[more]