Ontology highlight
ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC4663489 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Feng Jiaying J Gong Danyang D Fu Xudong X Wu Ting-Ting TT Wang Jane J Chang Jennifer J Zhou Jingting J Lu Gang G Wang Yibin Y Sun Ren R
Scientific reports 20151130
Viruses rely on host chaperone network to support their infection. In particular, the endoplasmic reticulum (ER) resident chaperones play key roles in synthesizing and processing viral proteins. Influx of a large amount of foreign proteins exhausts the folding capacity in ER and triggers the unfolded protein response (UPR). A fully-executed UPR comprises signaling pathways that induce ER folding chaperones, increase protein degradation, block new protein synthesis and may eventually activate apo ...[more]