Ontology highlight
ABSTRACT:
SUBMITTER: Sivaprakasam M
PROVIDER: S-EPMC4664181 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Sivaprakasam Mangaleswaran M Hansen Kasper B KB David Olivier O Nielsen Birgitte B Traynelis Stephen F SF Clausen Rasmus P RP Couty François F Bunch Lennart L
ChemMedChem 20090101 1
The four stereoisomers of azetidine-2,3-dicaroxylic acid (L-trans-ADC, L-cis-ADC, D-trans-ADC, and D-cis-ADC) were synthesized in a stereocontrolled fashion following two distinct strategies: one providing the two cis-ADC enantiomers and one giving access to the two trans-ADC enantiomers. The four azetidinic amino acids were characterized in a radioligand binding assay ([(3)H]CGP39653) at native NMDA receptors: L-trans-ADC showed the highest affinity (K(i)=10 microM) followed by the D-cis-ADC st ...[more]