Ontology highlight
ABSTRACT:
SUBMITTER: Cavalieri V
PROVIDER: S-EPMC4664418 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Cavalieri Vincenzo V Spinelli Giovanni G
PloS one 20151130 11
Dorsal/ventral patterning of the sea urchin embryo depends upon the establishment of a Nodal-expressing ventral organizer. Recently, we showed that spatial positioning of this organizer relies on the dorsal-specific transcription of the Hbox12 repressor. Building on these findings, we determined the influence of the epigenetic milieu on the expression of hbox12 and nodal genes. We find that Trichostatin-A, a potent and selective histone-deacetylases inhibitor, induces histone hyperacetylation in ...[more]