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Metagenomics: Retrospect and Prospects in High Throughput Age.


ABSTRACT: In recent years, metagenomics has emerged as a powerful tool for mining of hidden microbial treasure in a culture independent manner. In the last two decades, metagenomics has been applied extensively to exploit concealed potential of microbial communities from almost all sorts of habitats. A brief historic progress made over the period is discussed in terms of origin of metagenomics to its current state and also the discovery of novel biological functions of commercial importance from metagenomes of diverse habitats. The present review also highlights the paradigm shift of metagenomics from basic study of community composition to insight into the microbial community dynamics for harnessing the full potential of uncultured microbes with more emphasis on the implication of breakthrough developments, namely, Next Generation Sequencing, advanced bioinformatics tools, and systems biology.

SUBMITTER: Kumar S 

PROVIDER: S-EPMC4664791 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Metagenomics: Retrospect and Prospects in High Throughput Age.

Kumar Satish S   Krishnani Kishore Kumar KK   Bhushan Bharat B   Brahmane Manoj Pandit MP  

Biotechnology research international 20151117


In recent years, metagenomics has emerged as a powerful tool for mining of hidden microbial treasure in a culture independent manner. In the last two decades, metagenomics has been applied extensively to exploit concealed potential of microbial communities from almost all sorts of habitats. A brief historic progress made over the period is discussed in terms of origin of metagenomics to its current state and also the discovery of novel biological functions of commercial importance from metagenom  ...[more]

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